St. Catharines is located at the intersection of the QEW and Hwy-406 in southern Ontario, approx. 110 km south of Toronto (60 km directly across Lake Ontario) and approx. 60 km northwest of Buffalo.
From Toronto: QEW Niagara to St. Catharines, exit at Highway 406 and proceed approx. 4 km to Fourth Avenue. Turn right on Fourth Avenue, and proceed to the intersection; turn left on Louth Street. Travel approx. 1 km on Louth Street, and turn left on Ridley Road. Follow Ridley Road to the end, and enter the campus through the main gates.
From Buffalo: QEW east toward Toronto. Exit at Hwy-406/Port Colborne and proceed approx. 4 km to Fourth Avenue. Turn right on Fourth Avenue, and proceed to the intersection; turn left on Louth Street. Travel approx. 1 km on Louth Street, and turn left on Ridley Road. Follow Ridley Road to the end, and enter the campus through the main gates.